Alzheimer’s Could be Reversible: Study

A team of researchers from MIT have published a research that points towards the potential reversible nature of Alzheimer’s disease. The disease creates blocks through genetic mutations that are formed when the HCAC2 enzyme condenses all memory associated genes. After a while, the genes end up becoming unexpressed and therefore redundant, losing the ability to form new memories as well as recover previous ones. Theoretically, eliminating or inhibiting the HCAC2 enzyme can result in “curing” Alzheimer’s, but this is nearly impossible in practice through conventional methods.

New Method to Prevent Enzyme Binding

The MIT team of researchers could be sitting on a potential cure along these lines, as they are hoping to have found a way to completely prohibit the binding of Sp3 with the HCAC2 enzyme. This binding is essentially responsible for the genetic impediment that causes Alzheimer’s. And the solution could be the use of LED lights. The rudimentary passages of the research were actually founded from a discovery in 2007, where it was realized that blocking HDAC activity in lab mice could potentially reverse the memory loss in them. This was far more complicated to do in a human mind which contains numerous forms of HDAC. The MIT team eventually deduced it was HDAC2 that was the culprit and their research started revolving around it.

Finding the Key to Success

One of the trickier things the team had to figure out was to inhibit HDAC2 levels without touching the HDAC1 levels as that could end up being detrimental to the body’ white blood cell production rate. After analyzing postmortem brains, the team found thousands of genes that were close to HDAC2, from which they had to isolate the ones that interacted with the Sp3 gene.

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